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The Effect of Platelet-Rich Plasma (PRP) on the Healing of Allograft for the Treatment of Segmental Bone Defect of the Ulna in Rabbits
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Joo Hyun Song, Jinyoung Jeong, Yong Koo Kang, Han Yong Lee, Mun Ik Son, Sang Il Seo
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J Korean Soc Fract 2003;16(3):416-422. Published online July 31, 2003
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DOI: https://doi.org/10.12671/jksf.2003.16.3.416
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 Abstract
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- PURPOSE
The purpose of this study was to evaluate the effect of Platelet-Rich Plasma (PRP) on the healing of the allograft for the treatment of the segmental bone defect of the ulna in Rabbits.
MATERIALS AND METHODS
About 2 cm-sized segmental bone defects were created on both ulna of twenty rabbits. The rabbits were divided into two groups, even and odd number group after numbering them from 1 to 20. The segmental bone from the odd numbered animal was transplanted to the even numbered animal, and the even numbered to the odd numbered. The left side of the ulna of the animal is grafted with a segmental allograft only. The right side of the ulna was grafted with a segmental allograft and 0.7 cc of PRP. Radiographs obtained at 0, 4, 8, and 12 weeks postoperatively were graded for radiologic union.
RESULTS
The use of the combination of PRP and segmental allograft demonstrated improved healing on radiolographic study compared with that demonstrated after use of allogrft alone.
CONCLUSION
The results of the study suggests that the use of the combination of PRP and segmental allograft can be considered as an alternative method to manage the segmental defect of the long bone.
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Citations
Citations to this article as recorded by  - Effect of Different Bone Substitutes on the Concentration of Growth Factors in Platelet-rich Plasma
Hee Soon Cho, So-Young Park, Sukyoung Kim, Sang Keun Bae, Duk Seop Shin, Myun-Whan Ahn
Journal of Biomaterials Applications.2008; 22(6): 545. CrossRef
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